Modvigil 200mg

Modvigil 200 mg is a psychostimulant containing modafinil as an active ingredient that is used in dealing with Narcolepsy, Shift-work Disorder and Obstructive sleep Apnea. This may work by inhibiting dopamine reuptake by weakly blocking DAT transporter, also by increasing dopamine in prefrontal cortex and nucleus accumbens may increase alertness, focus, by activating orexin and hypocretin activation as narcolepsy patients may lacks orexin and here modafinil replaces that wake drive, the histamine in tuberomammillary nucleus may activates cortical. There is increase in excitatory glutamate and decreasing inhibitory GABA in wake-promoting areas.

Key Features

Usage

• It can be used in treating Narcolepsy.
• Obstructive Sleep Apnea (OSA) can also be treated.
• Shift-work Disorder can also be treated.

Dosage

• Modvigil 200 mg can be taken once a day, with or without food.
• Do not exceed the dose or doubled the dose when it is mistakenly skipped.
• It can be taken only after consulting your doctor or healthcare provider.

Side effects

• Depression
• Aggression
• Suicidal thoughts
• Nausea
• Diarrhea
• Anxiety
• Insomnia
• Dizziness

Interactions

• It may interact with hormonal contraceptives by decreasing its effectiveness.
• It may interact with cyclosporine by decreasing the level and increasing the transplant rejection risk.
• CYP2C19 drug may increase levels of diazepam, phenytoin, propranolol, and omeprazole and may increase the risk of side effects.
• CYP3A4 inducers like Rifampin, carbamazepine may decrease the modafinil level.
• MAOIs may cause hypertensive effects.
• Alcohol should be avoided while taking any such medications.

Pharmacokinetics

• It may reach to peak plasma concentration Tmax at 2-4 hours.
• Protein binding is approx. 60% mainly to albumin.
• Hepatic metabolism via CYP3A4/5.
• Half life is about 12-15 hours.
• It is excreted in through urine.

Precautions

• Pregnant and breast-feeding women should avoid taking Modvigil 100 mg.
• The one with prior medical condition of cardiac disease, psychiatric history, liver disease should avoid taking such medications.
• It is not approved for one who is under 17 years.
• Prior taking any such medications consult your healthcare provider to avoid unwanted interactions.

Conclusion

Modvigil 200 mg is a psychostimulant containing modafinil as an active ingredient that is used in dealing with Narcolepsy, Shift-work Disorder and Obstructive sleep Apnea. This may work by inhibiting dopamine reuptake by weakly blocking DAT transporter, also by increasing dopamine in prefrontal cortex and nucleus accumbens may increase alertness, focus. It may show some side effects like nausea, dizziness, headache, suicidal thoughts, anxiety, insomnia, aggression and depression. This side effects may vary from individual to individual and to avoid such unwanted interactions prior consult your doctor or healthcare provider.

FAQs

1. What for Modvigil 200 mg is used?
Modvigil 200 mg is a psychostimulant containing modafinil as an active ingredient that is used in dealing with Narcolepsy, Shift-work Disorder and Obstructive sleep Apnea.

2. How does Modvigil 200 mg work?
Modvigil 200 mg may work by inhibiting dopamine reuptake by weakly blocking DAT transporter, also by increasing dopamine in prefrontal cortex and nucleus accumbens may increase alertness, focus.

3. What can be the possible side effects of Modvigil 200 mg?
The possible side effects of Modvigil 200 mg can be nausea, dizziness, headache, suicidal thoughts, anxiety, insomnia, aggression and depression.

4. How fast does Modvigil 200 mg may works?
Modvigil 200 mg may reach the peak plasma level at just 2-4 hours.

5. What can be the ideal dose of Modvigil 200 mg?
The dosage can be depend upon the condition as for Narcolepsy and Obstructive Sleep Apnea Modvigil 200 mg can be taken once a day in morning, whereas in the condition of Shift work Disorder it can be taken 1 hour before shift.